PODOPHYLLOTOXIN, DEOXYPODOPHYLLOTOXIN AND URSOLIC ACID AS POTENTIAL INHIBITORS OF TCPA, OMPW, AND CTXB GENES IN VIBRIO CHOLERAE: AN IN-SILICO STUDY

Podophyllotoxin, Deoxypodophyllotoxin and Ursolic Acid as Potential Inhibitors of tcpA, ompW, and ctxB Genes in Vibrio cholerae: An in-Silico Study

Introduction: Cholera is a highly contagious disease that causes severe diarrhea and dehydration.This study investigated podophyllotoxin, deoxypodophyllotoxin, and ursolic acid as inhibitors of tcpA, ompW, and ctxB genes in Vibrio cholerae.Methods: We obtained the crystallized structure of podophyllotoxin, deoxypodophyllotoxin, and ursolic acid fro

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Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development

Abstract Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction.Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply principal component analysis (PCA) to seven Fast Freeze Cover Clip SDB-related measures.We estimate the associations of the top two S

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